hybrid N-glycan moiety
IRI: https://spec.industrialontologies.org/ontology/construct/HybridNGlycanMoiety
Defined In: https://spec.industrialontologies.org/ontology/biopharma/MolecularEntity/
SubClass Of: core pentasaccharide N-glycan moiety
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:independent continuant › bfo:material entity › chemical moiety › N-glycan moiety › core pentasaccharide N-glycan moiety › hybrid N-glycan moiety
Definition
core pentasaccharide N-glycan moiety that contains both unsubstituted terminal mannose residues and at least one mannose residue substituted by an N-acetylglucosamine unit
Examples
- Hybrid N-glycan moiety on a recombinant glycoprotein with one arm retaining terminal mannose residues and another arm extended with N-acetylglucosamine; Hybrid N-glycan moiety detected during glycan profiling of a therapeutic glycoprotein; Hybrid N-glycan moiety in which one branch has high-mannose character while another branch has complex-type extension.
Adapted From
- https://www.sigmaaldrich.com/RS/en/technical-documents/technical-article/protein-biology/protein-labeling-and-modification/n-glycans
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
This term is expected to remain primitive as the detailed treatment of chemical bonds, structure and formation is outside of the current scope of IOF. Other biological and chemical ontologies should be used for these purposes
Formal Axioms
First-Order Logic Axioms
HybridNGlycanMoiety(x) → CorePentasaccharideNGlycanMoiety(x)
Semi-Formal Natural Language Axioms
if x is a ‘hybrid N-glycan moiety’ then x is a ‘core pentasaccharide N-glycan moiety’