complex agalactosylated N-glycan moiety

IRI: https://spec.industrialontologies.org/ontology/construct/ComplexAGalactosylatedNGlycanMoiety

Defined In: https://spec.industrialontologies.org/ontology/biopharma/MolecularEntity/

SubClass Of: biantennary complex N-glycan moiety

Class Hierarchy

owl:Thing › bfo:entity › bfo:continuant › bfo:independent continuant › bfo:material entity › chemical moiety › N-glycan moiety › core pentasaccharide N-glycan moiety › biantennary complex N-glycan moiety › complex agalactosylated N-glycan moiety

Definition

biantennary complex N-glycan moiety that has no galactose residues as parts

Semi-Formal Definition:

every instance of ‘complex agalactosylated N-glycan moiety’ is defined as exactly an instance of ‘biantennary complex N-glycan moiety’ that ‘has proper continuant part at all times’ no ‘galactose residue’

Examples

• G0 biantennary complex N-glycan moiety with no galactose residues; G0F biantennary complex N-glycan moiety with core fucose but no galactose residues; Agalactosylated Fc N-glycan moiety detected in monoclonal antibody glycan profiling.

Adapted From

• https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-development-production-characterisation-and-specification-monoclonal-antibodies-and-related-products-revision-1_en.pdf and http://www.jbiomed.com/v04p0035.htm and https://pmc.ncbi.nlm.nih.gov/articles/PMC4634315/

Formal Axioms

First-Order Logic Definition

ComplexAGalactosylatedNGlycanMoiety(x) ↔ BiantennaryComplexNGlycanMoiety(x) ∧ ¬∃y (hasProperContinuantPartAtAllTimes(x, y) ∧ GalactoseResidue(y))

Description Logic

constr:ComplexAGalactosylatedNGlycanMoiety ≡ constr:BiantennaryComplexNGlycanMoiety ⊓ ¬ ∃ bfo:has_proper_continuant_part_at_all_times .constr:GalactoseResidue

constr:ComplexAGalactosylatedNGlycanMoiety ⊑ constr:BiantennaryComplexNGlycanMoiety

constr:ComplexAGalactosylatedNGlycanMoiety ⊓ constr:ComplexGalactosylatedNGlycanMoiety ⊑ ⊥

EquivalentTo: constr:BiantennaryComplexNGlycanMoiety and not bfo:has_proper_continuant_part_at_all_times some constr:GalactoseResidue

SubClassOf: constr:BiantennaryComplexNGlycanMoiety

constr:ComplexAGalactosylatedNGlycanMoiety DisjointWith: constr:ComplexGalactosylatedNGlycanMoiety