caking propensity

IRI: https://spec.industrialontologies.org/ontology/construct/CakingPropensity

Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaMaterial/

SubClass Of: bfo:disposition

Class Hierarchy

owl:Thing › bfo:entity › bfo:continuant › bfo:specifically dependent continuant › bfo:realizable entity › bfo:disposition › caking propensity

Definition

disposition of a particulate material entity to form persistent lumps, agglomerates, or a coherent solid mass

Explanatory Notes

Caking propensity is typically realized when a particulate material experiences environmental or mechanical conditions over time, such as during storage, transport, or handling. Conditions such as humidity or moisture exposure, temperature, applied pressure, self-weight consolidation, particle dissolution and recrystallization, electrostatic effects, and particle-particle adhesion can influence whether and how rapidly caking develops. Caking propensity should be distinguished from caked form, which is the material form resulting when caking has occurred, and from flowability, which concerns the capability of a material to flow under a handling or processing context.

Examples

• the caking propensity of powdered cell culture medium during storage under humid conditions; the caking propensity of a granulated medium during transport; the caking propensity of an excipient powder after exposure to moisture;

Adapted From

• https://www.sciencedirect.com/science/article/pii/S0032591017301511 and https://www.sciencedirect.com/science/article/abs/pii/S1004954118308747

Primitive Class

This class is declared primitive and it does not have necessary and sufficient condiftions defined.

Primitive Rationale

There are insufficient constructs for creating a set of necessary and sufficient conditions

Formal Axioms

First-Order Logic Axioms

CakingPropensity(x) → Disposition(x) ∧ ∃m (MaterialEntity(m) ∧ dispositionOf(x, m) ∧ ∃f (ParticulateForm(f) ∧ hasQuality(m, f)))

Semi-Formal Natural Language Axioms

if x is a ‘caking propensity’ then x is a ‘disposition’ that is the ‘disposition of’ some ‘material entity’ that ‘has quality’ some ‘particulate form’

Description Logic

constr:CakingPropensity ⊑ bfo:disposition

constr:CakingPropensity ⊑ ∃ constr:dispositionOf .(bfo:material_entity ⊓ ∃ constr:hasQuality .constr:ParticulateForm)

SubClassOf: bfo:disposition

SubClassOf: constr:dispositionOf some (bfo:material_entity and constr:hasQuality some constr:ParticulateForm)