cell bank

IRI: https://spec.industrialontologies.org/ontology/construct/CellBank

Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaMaterial/

SubClass Of: bfo:object aggregate

Class Hierarchy

owl:Thing › bfo:entity › bfo:continuant › bfo:independent continuant › bfo:material entity › bfo:object aggregate › cell bank

Direct subclasses:

• master cell bank
• working cell bank

Definition

object aggregate consisting of containers whose contents are uniform portions derived from a single pool of cells and that are stored under defined conditions as a referenceable source of cells

Explanatory Notes

The container contents of a cell bank are typically cryopreserved.

Examples

• a master cell bank used to generate working cell banks; a working cell bank used to inoculate production cultures;

Adapted From

• https://www.ema.europa.eu/en/documents/scientific-guideline/ich-q-5-d-derivation-and-characterisation-cell-substrates-used-production-biotechnologicalbiological-products-step-5_en.pdf and https://extranet.who.int/prequal/glossary-acronyms/s#:~:text=A%20master%20seed%20lot%20

Primitive Class

This class is declared primitive and it does not have necessary and sufficient condiftions defined.

Primitive Rationale

There are insufficient constructs to create a set of necessary and sufficient conditions.

Formal Axioms

First-Order Logic Axioms

CellBank(x) → ObjectAggregate(x)

Semi-Formal Natural Language Axioms

if x is a ‘cell bank’ then x is an ‘object aggregate’

Description Logic

constr:CellBank ⊑ bfo:object_aggregate

SubClassOf: bfo:object_aggregate