study design optimization objective
IRI: https://spec.industrialontologies.org/ontology/construct/StudyDesignOptimizationObjective
Defined In: https://spec.industrialontologies.org/ontology/biopharma/DesignOfExperiments/
SubClass Of: study design objective
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:generically dependent continuant › information content entity › objective specification › study design objective › study design optimization objective
Definition
study design objective that prescribes determining the combination of independent variable values under which the values of one or more dependent variables are optimal according to specified criteria
Explanatory Notes
Optimization objectives are used to estimate and model the quantitative relationships between selected independent variables and dependent variables. The goal is to find the factor settings that maximize or minimize the desired responses within the studied region. When multiple dependent variables are optimized simultaneously, trade-offs may be required. The predicted optimum is typically verified through confirmatory runs.
Examples
- Determining the load density, residence time, and wash pH that maximize step yield while maintaining predefined host-cell-protein clearance in a protein A capture step
Adapted From
- https://wolfson.huji.ac.il/purification/PDF/Others/GE_DOE_in_Protein_Production_and_Purification_Handbook.pdf
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
There are insufficient constructs to determine a set of necessary and sufficient conditions
Formal Axioms
First-Order Logic Axioms
StudyDesignOptimizationObjective(x) → StudyDesignObjective(x)
Semi-Formal Natural Language Axioms
if x is a ‘study design optimization objective’ then x is a ‘study design objective’