study design run
IRI: https://spec.industrialontologies.org/ontology/construct/StudyDesignRun
Defined In: https://spec.industrialontologies.org/ontology/biopharma/DesignOfExperiments/
SubClass Of: planned process
Class Hierarchy
owl:Thing › bfo:entity › bfo:occurrent › bfo:process › planned process › study design run
Definition
planned process that is an occurrent part of a study design execution and in which the factor levels of a single design point are applied
Semi-Formal Definition:
every instance of ‘study design run’ is defined as exactly an instance of ‘planned process’ that is an ‘occurrent part of’ some ‘study design execution’ prescribed by a ‘study design’ and ‘concretizes at some time’ exactly one ‘design point’ that is a ‘continuant part of at all times’ that same ‘study design’
Explanatory Notes
1) Saying that the factor levels are applied means that the run is set up or operated using those planned levels, for example by setting pH, temperature, feed concentration, agitation rate, buffer pH, resin load, or medium composition to the levels specified by the design point. Multiple study runs may apply the same design point when the study includes replicates. 2) In a split-plot design, each study design run is the process performed on an experimental unit under the complete combination of whole-plot and subplot factor levels specified by its design point. A containing whole-plot process may establish a factor level shared by several nested study design runs without itself being a study design run unless it applies one complete design point.
Examples
- In a cell-culture DoE used to study pH, temperature, and feed concentration, each bioreactor culture performed at one planned combination of those factor levels is a study run; In a media optimization study, each shake-flask culture prepared with one planned medium formulation is a study run; In a single factor pH study, each culture performed at one planned pH level while temperature, inoculum density, and feed conditions are held fixed is a study run; In a chromatography optimization study, each column operation performed at one planned combination of load density, flow rate, and buffer pH is a study run;
Formal Axioms
First-Order Logic Definition
StudyDesignRun(x) ↔ PlannedProcess(x) ∧ ∃e∃s∃d(StudyDesignExecution(e) ∧ StudyDesign(s) ∧ DesignPoint(d) ∧ occurrentPartOf(x,e) ∧ prescribedBy(e,s) ∧ continuantPartOfAtAllTimes(d,s) ∧ concretizesAtSomeTime(x,d) ∧ ∀d1((DesignPoint(d1) ∧ concretizesAtSomeTime(x,d1)) → d1=d))
Description Logic
constr:StudyDesignRun ≡ constr:PlannedProcess ⊓ ∃ bfo:concretizes_at_some_time .constr:DesignPoint ⊓ ∃ bfo:occurrent_part_of .bfo:None
EquivalentTo: constr:PlannedProcess and bfo:concretizes_at_some_time some constr:DesignPoint and bfo:occurrent_part_of some bfo:None
SubClassOf: constr:PlannedProcess