cell retention process

IRI: https://spec.industrialontologies.org/ontology/construct/CellRetentionProcess

Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaManufacturingExecution/

SubClass Of: planned process

Class Hierarchy

owl:Thing › bfo:entity › bfo:occurrent › bfo:process › planned process › cell retention process

Definition

planned process in which material is removed from a cell culture while cells are preferentially kept in or returned to the cell culture

Examples

• cell retention process in a perfusion cell culture process, in which cells are retained in the culture system while product-containing harvest is removed through an alternating tangential flow device; cell retention process in a perfusion culture process, in which cells are retained by tangential flow filtration while spent medium is removed; cell retention process in a culture process, in which a spin filter retains cells while culture fluid is withdrawn

Adapted From

• https://www.sigmaaldrich.com/RS/en/technical-documents/technical-article/pharmaceutical-and-biopharmaceutical-manufacturing/cell-retention-technology-intensified-upstream-processing?srsltid=AfmBOoqFH-ws3yWwAzIOto0QwogsWZ9HabmigGDMjpxvLiLAKJZ3UquQ

Primitive Class

This class is declared primitive and it does not have necessary and sufficient condiftions defined.

Primitive Rationale

Insufficient constructs are present to create a set of necessary and sufficient conditions.

Formal Axioms

First-Order Logic Axioms

CellRetentionProcess(x) → PlannedProcess(x) ∧ ∃c ((CellCulture(c) ∧ hasInput(x, c)) ∧ ∃r (MaterialRemovalProcess(r) ∧ hasOccurrentPart(x, r)) ∧ ∃p (PlannedProcess(p) ∧ occurrentPartOf(x, p) ∧ hasParticipantAtSomeTime(p, c)))

Semi-Formal Natural Language Axioms

if x is a ‘cell retention process’ then x is a ‘planned process’ that ‘has input’ some ‘cell culture’, ‘has occurrent part’ some ‘material removal process’, and is ‘occurrent part of’ some ‘planned process’ that ‘has participant at some time’ that same ‘cell culture’

Description Logic

constr:CellRetentionProcess ⊑ constr:PlannedProcess

constr:CellRetentionProcess ⊑ ∃ bfo:has_occurrent_part .constr:MaterialRemovalProcess

constr:CellRetentionProcess ⊑ ∃ bfo:occurrent_part_of .(constr:PlannedProcess ⊓ ∃ bfo:has_participant_at_some_time .constr:CellCulture)

constr:CellRetentionProcess ⊑ ∃ constr:hasInput .constr:CellCulture

SubClassOf: constr:PlannedProcess

SubClassOf: bfo:has_occurrent_part some constr:MaterialRemovalProcess

SubClassOf: bfo:occurrent_part_of some (constr:PlannedProcess and bfo:has_participant_at_some_time some constr:CellCulture)

SubClassOf: constr:hasInput some constr:CellCulture