protein high molecular weight variant classifier

IRI: https://spec.industrialontologies.org/ontology/construct/ProteinHighMolecularWeightVariantClassifier

Defined In: https://spec.industrialontologies.org/ontology/biopharma/MolecularEntity/

SubClass Of: protein size variant classifier

Class Hierarchy

owl:Thing › bfo:entity › bfo:continuant › bfo:generically dependent continuant › information content entity › denoter › classifier › size variant classifier › protein size variant classifier › protein high molecular weight variant classifier

Definition

protein size variant classifier that classifies a molecular entity population composed of proteins or protein aggregates as having greater molecular size or molecular weight than a reference protein form

Explanatory Notes

A protein high molecular weight variant classifier classifies protein-related molecular populations whose molecular size or molecular weight is greater than the reference protein form under the relevant analytical method. The classified population may include aggregates, dimers, oligomers, covalently linked forms, non-covalent associated forms, or other high-molecular-weight product-related material.

Examples

• a classifier that classifies the population corresponding to a high-molecular-weight species peak in a monoclonal antibody size exclusion chromatography-high performance liquid chromatography (SEC-HPLC) assay; a classifier that classifies antibody dimer and oligomer populations detected during aggregate analysis; a classifier that classifies soluble protein aggregate material observed as high-molecular-weight species relative to the monomer peak; a classifier that classifies covalent or non-covalent antibody aggregate populations detected in a drug substance lot;

Adapted From

• https://pmc.ncbi.nlm.nih.gov/articles/PMC3564875/ and https://pmc.ncbi.nlm.nih.gov/articles/PMC9980510/ and https://www.biopharminternational.com/view/protein-impurities-pose-challenges

Primitive Class

This class is declared primitive and it does not have necessary and sufficient condiftions defined.

Primitive Rationale

There are insufficient constructs to create a set of necessary and sufficient conditions.

Formal Axioms

First-Order Logic Axioms

ProteinHighMolecularWeightVariantClassifier(x) → ProteinSizeVariantClassifier(x) ∧ ∃p (MolecularEntityPopulation(p) ∧ classifies(x, p) ∧ ∃m ((Protein(m) ∨ ProteinAggregate(m)) ∧ hasMemberPartAtSomeTime(p, m)) ∧ ∀m (hasMemberPartAtSomeTime(p, m) → (Protein(m) ∨ ProteinAggregate(m))))

Semi-Formal Natural Language Axioms

if x is a ‘protein high molecular weight variant classifier’ then x is a ‘protein size variant classifier’ that classifies some ‘molecular entity population’ whose members are proteins or protein aggregates

Description Logic

constr:ProteinHighMolecularWeightVariantClassifier ⊑ constr:ProteinSizeVariantClassifier

constr:ProteinHighMolecularWeightVariantClassifier ⊑ ∃ constr:classifies .(constr:MolecularEntityPopulation ⊓ ∀ bfo:has_member_part_at_some_time .(constr:Protein ⊔ constr:ProteinAggregate))

constr:ProteinHighMolecularWeightVariantClassifier ⊓ constr:ProteinLowMolecularWeightVariantClassifier ⊑ ⊥

SubClassOf: constr:ProteinSizeVariantClassifier

SubClassOf: constr:classifies some (constr:MolecularEntityPopulation and bfo:has_member_part_at_some_time only (constr:Protein or constr:ProteinAggregate))

constr:ProteinHighMolecularWeightVariantClassifier DisjointWith: constr:ProteinLowMolecularWeightVariantClassifier