non-glycosylated molecular mass

IRI: https://spec.industrialontologies.org/ontology/construct/NonGlycosylatedMolecularMass

Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaMaterial/

SubClass Of: molecular mass

Class Hierarchy

owl:Thing › bfo:entity › bfo:continuant › bfo:specifically dependent continuant › bfo:quality › mass › molecular mass › non-glycosylated molecular mass

Definition

molecular mass of a glycoprotein or population of glycoproteins that characterizes the mass contribution of its non-glycan molecular structure

Explanatory Notes

1) Non-glycosylated molecular mass characterizes a glycoprotein or population of glycoproteins by the molecular mass attributable to the non-glycan portions of the molecular entities. 2) It is commonly determined by removing covalently attached glycans through an enzymatic or chemical deglycosylation process and measuring the molecular masses of the resulting molecular entities. 3) Non-glycosylated molecular mass should be distinguished from the intact molecular mass of the glycoform population, which includes the mass contributions of covalently attached glycans.

Examples

• the non-glycosylated molecular mass of a monoclonal antibody heavy chain after excluding attached N-glycans; the non-glycosylated molecular mass of a glycoprotein therapeutic after enzymatic deglycosylation; the deglycosylated molecular mass of an Fc-fusion protein after removal of covalently attached glycans

Synonyms

• non-glycosylated molecular weight

Adapted From

• https://www.fda.gov/media/182387/download

Primitive Class

This class is declared primitive and it does not have necessary and sufficient condiftions defined.

Primitive Rationale

There are insufficient constructs to define necessary and sufficient conditions.

Formal Axioms

First-Order Logic Axioms

NonGlycosylatedMolecularMass(x) → MolecularMass(x) ∧ ∃g ((Glycoprotein(g) ∨ (MolecularEntityPopulation(g) ∧ ∃p (Glycoprotein(p) ∧ hasMemberPartAtAllTimes(g, p)))) ∧ qualityOf(x, g))

Semi-Formal Natural Language Axioms

if x is a ‘non-glycosylated molecular mass’ then x is a ‘molecular mass’ that is the ‘quality of’ some ‘glycoprotein’ or some ‘molecular entity population’ that ‘has member part at all times’ some ‘glycoprotein’

Description Logic

constr:NonGlycosylatedMolecularMass ⊑ constr:MolecularMass

constr:NonGlycosylatedMolecularMass ⊑ ∃ constr:qualityOf .(constr:Glycoprotein ⊔ (constr:MolecularEntityPopulation ⊓ ∃ bfo:has_member_part_at_all_times .constr:Glycoprotein))

SubClassOf: constr:MolecularMass

SubClassOf: constr:qualityOf some (constr:Glycoprotein or (constr:MolecularEntityPopulation and bfo:has_member_part_at_all_times some constr:Glycoprotein))