molecular entity population

IRI: https://spec.industrialontologies.org/ontology/construct/MolecularEntityPopulation

Defined In: https://spec.industrialontologies.org/ontology/biopharma/MolecularEntity/

SubClass Of: bfo:object aggregate

Class Hierarchy

owl:Thing › bfo:entity › bfo:continuant › bfo:independent continuant › bfo:material entity › bfo:object aggregate › molecular entity population

Direct subclasses:

• protein charge variant population
• protein size variant population

Definition

object aggregate that has one or more molecular entities as member parts and has only molecular entities as member parts

Semi-Formal Definition:

every instance of ‘molecular entity population’ is defined as exactly an instance of ‘object aggregate’ that ‘has member part at some time’ some ‘molecular entity’ and ‘has member part at some time’ only ‘molecular entity’

Examples

• A population of monoclonal antibody molecules in a drug substance sample; A population of host cell protein molecules in a process intermediate; A population of product-related protein variant molecules in a recombinant protein batch; A population of released N-glycan molecules in a glycan profiling sample; A population of residual host cell DNA molecules in a drug substance sample; A population of peptide molecules generated during peptide mapping.

Formal Axioms

First-Order Logic Definition

MolecularEntityPopulation(x) ↔ ObjectAggregate(x) ∧ ∃y (hasMemberPartAtSomeTime(x, y) ∧ MolecularEntity(y)) ∧ ∀z (hasMemberPartAtSomeTime(x, z) → MolecularEntity(z))

Description Logic

constr:MolecularEntityPopulation ≡ bfo:object_aggregate ⊓ ∃ bfo:has_member_part_at_some_time .constr:MolecularEntity ⊓ ∀ bfo:has_member_part_at_some_time .constr:MolecularEntity

constr:MolecularEntityPopulation ⊑ bfo:object_aggregate

EquivalentTo: bfo:object_aggregate and bfo:has_member_part_at_some_time some constr:MolecularEntity and bfo:has_member_part_at_some_time only constr:MolecularEntity

SubClassOf: bfo:object_aggregate