molecular activity regulator role
IRI: https://spec.industrialontologies.org/ontology/construct/MolecularActivityRegulatorRole
Defined In: https://spec.industrialontologies.org/ontology/biopharma/MolecularEntity/
SubClass Of: molecular entity role
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:specifically dependent continuant › bfo:realizable entity › bfo:role › molecular entity role › molecular activity regulator role
Direct subclasses:
Definition
role held by a molecular entity when it modulates the activity of another molecular entity
Examples
- Allosteric inhibitor role held by a small molecule that reduces enzyme activity through non-covalent binding; Competitive inhibitor role held by a molecule that competes with a substrate for an enzyme active site; Receptor antagonist role held by a molecule that blocks receptor activation; Enzyme activator role held by a molecule that stabilizes an active enzyme conformation.
Adapted From
- http://purl.obolibrary.org/obo/GO_0098772 and http://purl.obolibrary.org/obo/TXPO_0003713
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
This term is expected to remain primitive as the detailed treatment of molecular activity modulation is outside of the current scope of IOF. Other biological and chemical ontologies should be used for these purposes
Formal Axioms
First-Order Logic Axioms
MolecularActivityRegulatorRole(x) → MolecularEntityRole(x)
Semi-Formal Natural Language Axioms
if x is a ‘molecular activity regulator role’ then x is a ‘molecular entity role’