growth factor role
IRI: https://spec.industrialontologies.org/ontology/construct/GrowthFactorRole
Defined In: https://spec.industrialontologies.org/ontology/biopharma/MolecularEntity/
SubClass Of: molecular messenger role
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:specifically dependent continuant › bfo:realizable entity › bfo:role › molecular entity role › molecular messenger role › growth factor role
Definition
role held by a peptide or protein that is realized in receptor-mediated signaling processes that stimulate cellular growth, proliferation, survival, or differentiation
Explanatory Notes
In culture media and biomanufacturing formulations, this role is typically asserted when a protein or peptide is intentionally added to support cell proliferation, maintain viability, promote differentiation, or enhance productivity.
Examples
- Role held by vascular endothelial growth factor (VEGF) that promotes endothelial proliferation; Role held by insulin-like growth factor 1 (IGF-1) that enhances recombinant protein production in mammalian cells
Adapted From
- http://purl.obolibrary.org/obo/GO_0008083
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
This term is expected to remain primitive as the detailed treatment of molecular messaging is outside of the current scope of IOF. Other biological and chemical ontologies should be used for these purposes
Formal Axioms
First-Order Logic Axioms
GrowthFactorRole(x) → MolecularMessengerRole(x) ∧ ∃y (roleOf(x, y) ∧ (Peptide(y) ∨ Protein(y)))
Semi-Formal Natural Language Axioms
if x is a ‘growth factor role’ then x is a ‘molecular messenger role’ and x is a ‘role of’ some ‘peptide’ or ‘protein’
Description Logic
constr:GrowthFactorRole ⊑ constr:MolecularMessengerRole
constr:GrowthFactorRole ⊑ ∃ constr:roleOf .(constr:Peptide ⊔ constr:Protein)
SubClassOf: constr:MolecularMessengerRole
SubClassOf: constr:roleOf some (constr:Peptide or constr:Protein)