enzyme regulator role
IRI: https://spec.industrialontologies.org/ontology/construct/EnzymeRegulatorRole
Defined In: https://spec.industrialontologies.org/ontology/biopharma/MolecularEntity/
SubClass Of: molecular activity regulator role
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:specifically dependent continuant › bfo:realizable entity › bfo:role › molecular entity role › molecular activity regulator role › enzyme regulator role
Direct subclasses:
Definition
role held by a molecular entity when it binds to an enzyme and modulates its catalytic activity
Examples
- ATP bearing an enzyme regulator role when it allosterically inhibits phosphofructokinase; A small-molecule bearing a competitive inhibitor role when binding to an enzyme active site; Calcium ion bearing an enzyme regulator role when it non-covalently activates a calcium-dependent enzyme; Role held by an allosteric activator that increases enzyme catalytic activity by stabilizing an active conformation
Adapted From
- http://purl.obolibrary.org/obo/TXPO_0003722 and http://purl.obolibrary.org/obo/GO_0030234
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
This term is expected to remain primitive as the detailed treatment of molecular activity modulation is outside of the current scope of IOF. Other biological and chemical ontologies should be used for these purposes
Formal Axioms
First-Order Logic Axioms
EnzymeRegulatorRole(x) → MolecularActivityRegulatorRole(x)
Semi-Formal Natural Language Axioms
if x is an ‘enzyme regulator role’ then x is a ‘molecular activity regulator role’