cell banking

IRI: https://spec.industrialontologies.org/ontology/construct/CellBanking

Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaManufacturingExecution/

SubClass Of: planned process

Class Hierarchy

owl:Thing › bfo:entity › bfo:occurrent › bfo:process › planned process › cell banking

Definition

planned process of preserving and maintaining a cell line for future use

Explanatory Notes

1) Cell banking provides a reliable and consistent source of a cell line for future use, reducing the need for continued propagation and helping to mitigate risks associated with genetic drift or contamination. 2) Examples of future use include research, drug development, and manufacturing of biopharmaceuticals.

Examples

• establishing a master cell bank by freezing portions of a cloned HEK293 cell line under GMP conditions; banking the Vero cell line in cryopreservation medium supplemented with DMSO (dimethyl sulfoxide) and storing it in vapor-phase liquid nitrogen for future vaccine manufacturing; banking a hybridoma cell line after single-cell cloning and characterization to provide a preserved source of cells for monoclonal antibody production

Primitive Class

This class is declared primitive and it does not have necessary and sufficient condiftions defined.

Primitive Rationale

Insufficient constructs are present to create a set of necessary and sufficient conditions

Formal Axioms

First-Order Logic Axioms

CellBanking(x) → PlannedProcess(x) ∧ ∃y (CellLine(y) ∧ hasParticipantAtSomeTime(x, y))

Semi-Formal Natural Language Axioms

if x is a ‘cell banking’ then x is a ‘planned process’ that ‘has participant at some time’ some ‘cell line’

Description Logic

constr:CellBanking ⊑ constr:PlannedProcess

constr:CellBanking ⊑ ∃ bfo:has_participant_at_some_time .constr:CellLine

SubClassOf: constr:PlannedProcess

SubClassOf: bfo:has_participant_at_some_time some constr:CellLine