planned transduction process
IRI: https://spec.industrialontologies.org/ontology/construct/PlannedTransductionProcess
Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaManufacturingExecution/
SubClass Of: genetic transformation process
Class Hierarchy
owl:Thing › bfo:entity › bfo:occurrent › bfo:process › planned process › genetic transformation process › planned transduction process
Definition
genetic transformation process of introducing DNA or RNA into cells by a virus or viral vector to modify the cell’s genetic material
Explanatory Notes
This class is restricted to planned applications of transduction, such as therapeutic, manufacturing, or experimental procedures. Examples include lentiviral transduction of T cells in CAR-T therapy, adeno-associated viral (AAV) gene delivery in gene therapy, and bacteriophage-mediated gene transfer in synthetic biology. Natural occurrences of transduction (e.g., bacteriophage-driven horizontal gene transfer in the environment) are out of scope and can be captured through external biological process ontologies (e.g., transduction in GO).
Examples
- Lentiviral transduction of primary human T cells in CAR-T manufacturing; AAV-mediated delivery of a therapeutic gene to retinal cells in gene therapy; Engineered phage transduction of E. coli in a laboratory setting
Counter-Examples
- Lipofection of plasmid DNA into CHO cells; Natural bacteriophage transfer of genes between gut bacteria
Adapted From
- http://id.nlm.nih.gov/mesh/D014161 and https://www.sciencedirect.com/topics/medicine-and-dentistry/genetic-transduction
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
Insufficient constructs are present to create a set of necessary and sufficient conditions
Formal Axioms
First-Order Logic Axioms
PlannedTransductionProcess(x) → GeneticTransformationProcess(x)
Semi-Formal Natural Language Axioms
if x is a ‘planned transduction process’ then x is a ‘genetic transformation process’