metabolite uptake rate

IRI: https://spec.industrialontologies.org/ontology/construct/MetaboliteUptakeRate

Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaParameter/

SubClass Of: rate process profile

Class Hierarchy

owl:Thing › bfo:entity › bfo:occurrent › bfo:process › bfo:process profile › rate process profile › metabolite uptake rate

Definition

rate process profile at which a metabolite is taken up by cells within a cell culture

Examples

• glucose uptake rate by a CHO cell population during fed-batch cultivation; glutamine uptake rate by a mammalian cell culture during early growth phase; amino acid uptake rate by a cell population during a nutrient-limited culture process;

Primitive Class

This class is declared primitive and it does not have necessary and sufficient condiftions defined.

Primitive Rationale

There are insufficient constructs to create necessary and sufficient conditions.

Formal Axioms

First-Order Logic Axioms

MetaboliteUptakeRate(x) → RateProcessProfile(x) ∧ ∃p(Process(p) ∧ processProfileOf(x,p) ∧ ∃c(CellCulture(c) ∧ hasParticipantAtSomeTime(p,c))) ∧ ∃me(MolecularEntity(me) ∧ hasParticipantAtSomeTime(x,me))

Semi-Formal Natural Language Axioms

if x is a ‘metabolite uptake rate’ then x is a ‘rate process profile’ that is the ‘process profile of’ some ‘process’ that ‘has participant at some time’ some ‘cell culture’ and x ‘has participant at some time’ some ‘molecular entity’

Description Logic

constr:MetaboliteUptakeRate ⊑ constr:RateProcessProfile

constr:MetaboliteUptakeRate ⊑ ∃ bfo:has_participant_at_some_time .constr:MolecularEntity

constr:MetaboliteUptakeRate ⊑ ∃ constr:processProfileOf .(bfo:process ⊓ ∃ bfo:has_participant_at_some_time .constr:CellCulture)

SubClassOf: constr:RateProcessProfile

SubClassOf: bfo:has_participant_at_some_time some constr:MolecularEntity

SubClassOf: constr:processProfileOf some (bfo:process and bfo:has_participant_at_some_time some constr:CellCulture)