serum
IRI: https://spec.industrialontologies.org/ontology/construct/Serum
Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaMaterial/
SubClass Of: mixed material
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:independent continuant › bfo:material entity › mixed material › serum
Definition
mixed material that is obtained from blood following coagulation and removal of cells and clotting factors
Explanatory Notes
Serum is added to cell culture media as a complex, biologically derived supplement that supports cell viability and growth. It provides a broad spectrum of nutrients, growth factors, hormones, carrier proteins, and attachment or protective factors that collectively promote proliferation and maintain homeostasis in cultured cells. Because serum is obtained from blood and not chemically defined, its molecular composition can vary significantly between production lots and source populations.
Examples
- fetal bovine serum used as a cell culture supplement; bovine serum used in mammalian cell culture medium; human serum used in specialized cell culture applications; heat-inactivated serum used during cell culture;
Adapted From
- https://www.cancer.gov/publications/dictionaries/cancer-terms/def/serum and https://aiche.onlinelibrary.wiley.com/doi/10.1002/btpr.2706 and https://www.sigmaaldrich.com/RS/en/technical-documents/technical-article/cell-culture-and-cell-culture-analysis/mammalian-cell-culture/serum-cell-tissue-faq?srsltid=AfmBOoqsTcOCHsAwgJqKH161qBbhuNQnVpAj3Pp091G9mogrrQMyek82
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
This term is expected to remain primitive
Formal Axioms
First-Order Logic Axioms
Serum(x) → MixedMaterial(x)
Semi-Formal Natural Language Axioms
if x is ‘serum’ then x is a ‘mixed material’
Description Logic
SubClassOf: constr:MixedMaterial