material functional inducer

IRI: https://spec.industrialontologies.org/ontology/construct/MaterialFunctionalInducer

Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaMaterial/

SubClass Of: bfo:material entity

Class Hierarchy

owl:Thing › bfo:entity › bfo:continuant › bfo:independent continuant › bfo:material entity › material functional inducer

Direct subclasses:

• material differentiation inducer
• material metabolic inducer
• material production inducer

Definition

material entity with a material functional inducer role

Semi-Formal Definition:

every instance of ‘material functional inducer’ is defined as exactly an instance of ‘material entity’ that ‘has role’ some ‘material functional inducer role’

Explanatory Notes

See the expanded definition under the corresponding role class. The term is formalized here as a defined class by referring to its corresponding role class and exists primarily for ontological modeling and implementation convenience.

Examples

• IL-7 and IL-15 solutions are used as differentiation inducers when added to CAR-T cell cultures to promote memory T-cell phenotype; Tetracycline is a production inducer when added to a mammalian cell culture to activate a Tet-regulated promoter driving recombinant protein expression.

Formal Axioms

First-Order Logic Definition

MaterialFunctionalInducer(x) ↔ MaterialEntity(x) ∧ ∃r(MaterialFunctionalInducerRole(r) ∧ hasRole(x, r))

Description Logic

constr:MaterialFunctionalInducer ≡ bfo:material_entity ⊓ ∃ constr:hasRole .constr:MaterialFunctionalInducerRole

constr:MaterialFunctionalInducer ⊑ bfo:material_entity

EquivalentTo: bfo:material_entity and constr:hasRole some constr:MaterialFunctionalInducerRole

SubClassOf: bfo:material_entity