culture feeding strategy
IRI: https://spec.industrialontologies.org/ontology/construct/CultureFeedingStrategy
Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaManufacturingExecution/
SubClass Of: plan specification
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:generically dependent continuant › information content entity › plan specification › culture feeding strategy
Definition
plan specification that prescribes how one or more feeding processes are to be executed during a cell culture process, including scheduling and amounts or rates, and any specified triggering conditions
Explanatory Notes
A feeding strategy specifies how feeding processes are to be executed, rather than performing them. It defines scheduling and frequency and may also specify decision rules that determine feed additions, such as fixed pre-set schedules, condition-based triggers based on process measurements, or model-based rules. As a plan specification, it serves as a template guiding execution of one or more feeding processes. Feeding strategies are commonly used to maintain favorable culture conditions, sustain cell growth, and support or optimize product accumulation.
Examples
- periodic bolus feeding strategy for CHO fed-batch cultures; dual-feed strategy combining separate carbohydrate and amino acid/vitamin feeds in CHO cultivation; exponential feeding strategy maintaining a defined specific growth rate in E. coli fed-batch process; model-predictive feeding strategy controlling nutrient supply in CHO perfusion culture
Adapted From
- https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/315/296/t099.pdf?srsltid=AfmBOorDj4GQApYbLofXthe35elxKxxnoghM-lzOSFnGvMAqW5HEJnG1 and https://pubmed.ncbi.nlm.nih.gov/20014108/ and https://www.tandfonline.com/doi/full/10.1080/10826068.2021.1998112
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
There are insufficient constructs to create a set of necessary and sufficient conditions.
Formal Axioms
First-Order Logic Axioms
CultureFeedingStrategy(x) → PlanSpecification(x) ∧ ∃p (CultureFeedAdditionProcess(p) ∧ prescribes(x, p))
Semi-Formal Natural Language Axioms
if x is a ‘culture feeding strategy’ then x is a ‘plan specification’ that ‘prescribes’ some ‘culture feed addition process’