heterodimeric antibody
IRI: https://spec.industrialontologies.org/ontology/construct/HeterodimericAntibody
Defined In: https://spec.industrialontologies.org/ontology/biopharma/MolecularEntity/
SubClass Of: antibody
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:independent continuant › bfo:material entity › molecular entity › organic molecular entity › protein › antibody › heterodimeric antibody
Definition
antibody consisting of two heavy chains and two light chains in which the two heavy chains differ in amino acid sequence, the two light chains differ in amino acid sequence, or both
Examples
- Bispecific IgG-like antibody with two different heavy chains; Heterodimeric monoclonal antibody engineered with knob-into-hole heavy-chain pairing; Antibody containing one heavy chain specific for antigen A and another heavy chain specific for antigen B.
Adapted From
- https://www.cytivalifesciences.com/en/us/insights/capture-of-bispecific-antibodies-and-removal-of-product-related-impurities
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
There are insufficient constructs to define a set of necessary and sufficient conditions.
Formal Axioms
First-Order Logic Axioms
HeterodimericAntibody(x) → Antibody(x)
Semi-Formal Natural Language Axioms
if x is a ‘heterodimeric antibody’ then x is an ‘antibody’
Description Logic
SubClassOf: constr:Antibody