inoculation process

IRI: https://spec.industrialontologies.org/ontology/construct/InoculationProcess

Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaManufacturingExecution/

SubClass Of: material addition process

Class Hierarchy

owl:Thing › bfo:entity › bfo:occurrent › bfo:process › planned process › material addition process › inoculation process

Direct subclasses:

• cell culture inoculation process
• virus inoculation process

Definition

material addition process in which cells, microorganisms, viruses, or biological preparations are deliberately introduced into a defined recipient to initiate growth, infection, testing, production, or a biological response

Explanatory Notes

1) In the context of inoculation, biological preparations refer to non-living, biologically derived materials that are intentionally introduced to elicit a response or initiate a process. This category includes vaccines (live-attenuated, inactivated, or subunit), purified antigens, toxoids, inactivated microorganisms, viral particles, and similar immunobiological products. Unlike cells, microorganisms, or viruses, biological preparations do not replicate autonomously but are used to stimulate, test, or modulate biological systems. 2) Defined recipient in this case encompasses medium, host, or vessel.

Examples

• After thawing, CHO cells are introduced into a shake flask containing fresh medium to initiate expansion; A starter culture of Saccharomyces cerevisiae is added to a fermenter to begin beer production; A viral stock is added to a mammalian cell culture to study infection dynamics; An inactivated influenza vaccine preparation is injected into a host organism to stimulate an immune response.

Adapted From

• http://purl.obolibrary.org/obo/NCIT_C68774 and https://database.ich.org/sites/default/files/ICH_Q5A%28R2%29_Guideline_2023_1101.pdf

Primitive Class

This class is declared primitive and it does not have necessary and sufficient condiftions defined.

Primitive Rationale

There are insufficient constructs present to create a set of necessary and sufficient conditions.

Formal Axioms

First-Order Logic Axioms

InoculationProcess(x) → MaterialAdditionProcess(x) ∧ ∃m ∃r ∃tr (MaterialEntity(m) ∧ InoculumRole(r) ∧ TransferredMaterialRole(tr) ∧ hasInput(x, m) ∧ hasRole(m, r) ∧ hasRole(m, tr))

Semi-Formal Natural Language Axioms

if x is an ‘inoculation process’ then x is a ‘material addition process’ that ‘has input’ some ‘material entity’ that ‘has role’ some ‘inoculum role’ and ‘transferred material role’

Description Logic

constr:InoculationProcess ⊑ constr:MaterialAdditionProcess

constr:InoculationProcess ⊑ ∃ constr:hasInput .(bfo:material_entity ⊓ ∃ constr:hasRole .constr:InoculumRole ⊓ ∃ constr:hasRole .constr:TransferredMaterialRole)

SubClassOf: constr:MaterialAdditionProcess

SubClassOf: constr:hasInput some (bfo:material_entity and constr:hasRole some constr:InoculumRole and constr:hasRole some constr:TransferredMaterialRole)