particulate load
IRI: https://spec.industrialontologies.org/ontology/construct/ParticulateLoad
Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaReferenceOntologyAttributes/
SubClass Of: bfo:quality
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:specifically dependent continuant › bfo:quality › particulate load
Definition
quality of a material entity that is the extent to which particulate matter is present in the material entity
Examples
- Particulate load of a drug product sample measured as the number of subvisible particles per mL; Particulate load of a buffer preparation assessed before filtration; Particulate load of a process intermediate after a hold step; Particulate load of a cell culture medium lot assessed during release testing; Particulate load of a formulation sample assessed by visual inspection for visible particles; Particulate load of purified water monitored as part of water-system quality control.
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
There are insufficient constructs for creating a set of necessary and sufficient conditions
Formal Axioms
First-Order Logic Axioms
ParticulateLoad(x) → Quality(x) ∧ ∃m(MaterialEntity(m) ∧ qualityOf(x,m) ∧ ∀p(hasMagnitudeBasisInBearerPart(x,p) → (MaterialEntity(p) ∧ continuantPartOfAtSomeTime(p,m) ∧ ∃f(ParticulateForm(f) ∧ hasQuality(p,f)))))
Semi-Formal Natural Language Axioms
if x is a ‘particulate load’ then x is a ‘quality’ that is the ‘quality of’ some ‘material entity’ m, and if x ‘has magnitude basis in bearer part’ some p, then p is a ‘material entity’ that is a ‘continuant part of at some time’ m and ‘has quality’ some ‘particulate form’
Description Logic
constr:ParticulateLoad ⊑ bfo:quality
constr:ParticulateLoad ⊑ ∀ constr:hasMagnitudeBasisInBearerPart .(bfo:material_entity ⊓ ∃ constr:hasQuality .constr:ParticulateForm)
constr:ParticulateLoad ⊑ ∃ constr:qualityOf .bfo:material_entity
SubClassOf: bfo:quality
SubClassOf: constr:hasMagnitudeBasisInBearerPart only (bfo:material_entity and constr:hasQuality some constr:ParticulateForm)
SubClassOf: constr:qualityOf some bfo:material_entity