perfusion medium exchange process
IRI: https://spec.industrialontologies.org/ontology/construct/PerfusionMediumExchangeProcess
Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaManufacturingExecution/
SubClass Of: culture medium exchange process
Class Hierarchy
owl:Thing › bfo:entity › bfo:occurrent › bfo:process › planned process › culture medium exchange process › perfusion medium exchange process
Definition
culture medium exchange process in which fresh culture medium is added to a cell culture while material is continuously or quasi-continuously removed from the cell culture, with cell retention used to preferentially keep cells in the culture
Examples
- perfusion culture medium exchange in a CHO perfusion culture, where fresh medium is supplied while product-containing harvest is removed through an Alternating Tangential Flow (ATF) cell retention device; perfusion culture medium exchange in a high-cell-density mammalian cell culture, where fresh medium is added while spent medium or harvest is removed through tangential-flow filtration; perfusion culture medium exchange using a spin filter, where medium is exchanged while cells are preferentially kept in the culture
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
There are insufficient constructs to create a set of necessary and sufficient conditions.
Formal Axioms
First-Order Logic Axioms
PerfusionMediumExchangeProcess(x) → CultureMediumExchangeProcess(x) ∧ ∃r (CellRetentionProcess(r) ∧ hasOccurrentPart(x, r))
Semi-Formal Natural Language Axioms
if x is a ‘perfusion medium exchange process’ then x is a ‘culture medium exchange process’ that ‘has occurrent part’ some ‘cell retention process’
Description Logic
constr:PerfusionMediumExchangeProcess ⊑ constr:CultureMediumExchangeProcess
constr:PerfusionMediumExchangeProcess ⊑ ∃ bfo:has_occurrent_part .constr:CellRetentionProcess
SubClassOf: constr:CultureMediumExchangeProcess
SubClassOf: bfo:has_occurrent_part some constr:CellRetentionProcess