glycosylated residue
IRI: https://spec.industrialontologies.org/ontology/construct/GlycosylatedResidue
Defined In: https://spec.industrialontologies.org/ontology/biopharma/MolecularEntity/
SubClass Of: glycoconjugated residue
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:independent continuant › bfo:material entity › chemical moiety › amino acid residue › modified amino acid residue › glycoconjugated residue › glycosylated residue
Direct subclasses:
Definition
glycoconjugated residue that results from replacement of a hydrogen atom with a carbohydrate-like group through formation of a glycosidic bond
Explanatory Notes
This class differs from glycation-derived glycoconjugated residues because the carbohydrate group is attached through an enzymatically formed glycosidic bond. In biopharmaceutical proteins, glycosylated residues commonly arise through regulated enzymatic glycosylation pathways, such as N-linked glycosylation of asparagine or O-linked glycosylation of serine or threonine. For many secreted mammalian proteins, these pathways occur through the endoplasmic reticulum and Golgi apparatus. In contrast, glycated residues arise through non-enzymatic reactions during manufacturing, formulation, or storage, such as reactions with reducing sugars that form Schiff-base or Amadori-type ketosamine adducts.
Examples
- N-glycosylated asparagine residue in a monoclonal antibody Fc region; O-glycosylated serine residue in a glycoprotein; O-glycosylated threonine residue in a mucin-like domain; Glycosylated asparagine residue carrying an N-linked glycan produced through enzymatic glycosylation.
Adapted From
- http://purl.obolibrary.org/obo/MOD_00693
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
This term is expected to remain primitive as the detailed treatment of chemical bonds, structure and formation is outside of the current scope of IOF. Other biological and chemical ontologies should be used for these purposes
Formal Axioms
First-Order Logic Axioms
GlycosylatedResidue(x) → GlycoconjugatedResidue(x)
Semi-Formal Natural Language Axioms
if x is a ‘glycosylated residue’ then x is a ‘glycoconjugated residue’