perfusion culture process operating mode

IRI: https://spec.industrialontologies.org/ontology/construct/PerfusionCultureProcessOperatingMode

Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaManufacturingExecution/

SubClass Of: continuous culture process operating mode

Class Hierarchy

owl:Thing › bfo:entity › bfo:continuant › process characteristic › planned process operating mode › continuous process operating mode › continuous culture process operating mode › perfusion culture process operating mode

Definition

continuous culture process operating mode in which culture medium or other input material is introduced while spent medium or product-containing harvest material is concomitantly removed over an operating interval, with cell retention used to preferentially keep cells in the culture system

Examples

• perfusion culture operating mode of a mammalian cell culture process, in which fresh medium is introduced while product-containing harvest is removed through a cell retention device; perfusion culture operating mode of a high-cell-density culture process, in which medium exchange supports cultivation while cells are retained in the culture system

Adapted From

• https://www.cytivalifesciences.com/en/us/insights/what-are-the-different-types-of-bioreactors and https://infors-ht.com/en/blog/the-difference-between-batch-fed-batch-and-continuous-processes

Primitive Class

This class is declared primitive and it does not have necessary and sufficient condiftions defined.

Primitive Rationale

There are insufficient constructs to define a set of necessary and sufficient conditions

Formal Axioms

First-Order Logic Axioms

PerfusionCultureProcessOperatingMode(x) → ContinuousCultureProcessOperatingMode(x) ∧ ∃p (PlannedProcess(p) ∧ processCharacteristicOf(x, p) ∧ ∃r (CellRetentionProcess(r) ∧ hasOccurrentPart(p, r)) ∧ ∃e (PerfusionMediumExchangeProcess(e) ∧ hasOccurrentPart(p, e)))

Semi-Formal Natural Language Axioms

if x is a ‘perfusion culture process operating mode’ then x is a ‘continuous culture process operating mode’ that is the ‘process characteristic of’ some ‘planned process’ that ‘has occurrent part’ some ‘cell retention process’ and ‘has occurrent part’ some ‘perfusion medium exchange process’

Description Logic

constr:PerfusionCultureProcessOperatingMode ⊑ constr:ContinuousCultureProcessOperatingMode

constr:PerfusionCultureProcessOperatingMode ⊑ ∃ constr:processCharacteristicOf .(constr:PlannedProcess ⊓ ∃ bfo:has_occurrent_part .constr:CellRetentionProcess ⊓ ∃ bfo:has_occurrent_part .constr:PerfusionMediumExchangeProcess)

SubClassOf: constr:ContinuousCultureProcessOperatingMode

SubClassOf: constr:processCharacteristicOf some (constr:PlannedProcess and bfo:has_occurrent_part some constr:CellRetentionProcess and bfo:has_occurrent_part some constr:PerfusionMediumExchangeProcess)