target value expression
IRI: https://spec.industrialontologies.org/ontology/construct/TargetValueExpression
Defined In: https://spec.industrialontologies.org/ontology/biopharma/TargetsLimitsRanges/
SubClass Of: value expression
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:generically dependent continuant › information content entity › value expression › target value expression
Direct subclasses:
Definition
value expression which is a prescribed value that a quality attribute, material attribute, performance indicator, or process parameter should have at a particular time point or during a particular time interval of some planned process
Explanatory Notes
For material attributes, a target value may prescribe the required attribute value of an input material, such as a raw material, intermediate, or prepared solution, at a specified checkpoint in the planned process, for example at material receipt, at lot release, or at the time the material is introduced into the process
Examples
- 37 °C as the target value for bioreactor temperature during cell culture; pH 7.2 as the target value for a prepared buffer before use; 300 mOsm/kg as the target osmolality for a prepared media lot at release; 95 % viability as the target value for a cell culture before inoculation; 5.0 g/L as the target product concentration at harvest
Synonyms
- target value
Adapted From
- https://www.ema.europa.eu/en/documents/scientific-guideline/ich-guideline-q11-development-and-manufacture-drug-substances-chemical-entities-and-biotechnologicalbiological-entities_en.pdf
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
There are insufficient constructs to create necessary and sufficient conditions.
Formal Axioms
First-Order Logic Axioms
TargetValueExpression(x) → ValueExpression(x)
Semi-Formal Natural Language Axioms
If x is a ‘target value expression’ then x is a ‘value expression’