viable cell density

IRI: https://spec.industrialontologies.org/ontology/construct/ViableCellDensity

Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaMaterial/

SubClass Of: cell density

Class Hierarchy

owl:Thing › bfo:entity › bfo:continuant › bfo:specifically dependent continuant › bfo:quality › bfo:relational quality › density › number density › cell density › viable cell density

Definition

cell density that is the number of viable cells per unit size

Explanatory Notes

Viable cell density accounts only for cells that are alive and capable of maintaining essential physiological activities such as metabolism, growth, and proliferation. It is commonly reported as viable cells per unit volume, such as cells/mL, or viable cells per unit area, such as cells/cm².

Examples

• the viable cell density of a CHO cell culture during production; the viable cell density of a bioreactor culture sample measured by an automated cell counter; the viable cell density of a seed train culture before inoculation;

Adapted From

• https://www.sartorius.com/download/501934/online-monitoring-of-viable-cell-concentrations-in-small-bioreactors-data.pdf and http://purl.allotrope.org/ontologies/quality#AFQ_0000182

Primitive Class

This class is declared primitive and it does not have necessary and sufficient condiftions defined.

Primitive Rationale

There are insufficient constructs for creating a set of necessary and sufficient conditions.

Formal Axioms

First-Order Logic Axioms

ViableCellDensity(x) → CellDensity(x) ∧ ∀p(hasMagnitudeBasisInBearerPart(x,p) → (Cell(p) ∧ ∃d(Viable(d) ∧ hasQuality(p,d))))

Semi-Formal Natural Language Axioms

if x is a ‘viable cell density’ then x is a ‘cell density’, and if x ‘has magnitude basis in bearer part’ some p, then p is a ‘cell’ that ‘has quality’ some ‘viable’

Description Logic

constr:ViableCellDensity ⊑ constr:CellDensity

constr:ViableCellDensity ⊑ ∀ constr:hasMagnitudeBasisInBearerPart .(constr:Cell ⊓ ∃ constr:hasQuality .constr:Viable)

SubClassOf: constr:CellDensity

SubClassOf: constr:hasMagnitudeBasisInBearerPart only (constr:Cell and constr:hasQuality some constr:Viable)