cell density

IRI: https://spec.industrialontologies.org/ontology/construct/CellDensity

Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaMaterial/

SubClass Of: number density

Class Hierarchy

owl:Thing › bfo:entity › bfo:continuant › bfo:specifically dependent continuant › bfo:quality › bfo:relational quality › density › number density › cell density

Direct subclasses:

• dead cell density
• total cell density
• viable cell density

Definition

number density that is the number of cells per unit size

Explanatory Notes

Cell density is commonly reported as cells per unit volume (e.g. cells/mL) or cells per unit area (e.g. cells/cm²), depending on how the cell population is distributed in the material entity being studied. It characterizes how many cells occupy a specified portion of material space and is an important parameter for interpreting cellular behavior such as growth, viability, differentiation, gene expression, and responses to environmental conditions. In practice, cell density may be obtained by direct or automated counting methods or indirectly from surrogate readouts such as optical density at 600 nm (OD600).

Examples

• the total cell density of a bioreactor culture sample; the viable cell density of a CHO cell culture during production; the dead cell density of a stressed culture sample after viability analysis;

Adapted From

• http://purl.allotrope.org/ontologies/quality#AFQ_0000181

Primitive Class

This class is declared primitive and it does not have necessary and sufficient condiftions defined.

Primitive Rationale

There are insufficient constructs for creating a set of necessary and sufficient conditions.

Formal Axioms

First-Order Logic Axioms

CellDensity(x) → NumberDensity(x) ∧ ∀p(hasMagnitudeBasisInBearerPart(x,p) → Cell(p))

Semi-Formal Natural Language Axioms

if x is a ‘cell density’ then x is a ‘number density’, and if x ‘has magnitude basis in bearer part’ some p, then p is a ‘cell’

Description Logic

constr:CellDensity ⊑ constr:NumberDensity

constr:CellDensity ⊑ ∀ constr:hasMagnitudeBasisInBearerPart .constr:Cell

SubClassOf: constr:NumberDensity

SubClassOf: constr:hasMagnitudeBasisInBearerPart only constr:Cell