study design screening objective
IRI: https://spec.industrialontologies.org/ontology/construct/StudyDesignScreeningObjective
Defined In: https://spec.industrialontologies.org/ontology/biopharma/DesignOfExperiments/
SubClass Of: study design objective
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:generically dependent continuant › information content entity › objective specification › study design objective › study design screening objective
Definition
study design objective that prescribes identifying which independent variables impact one or more dependent variables
Explanatory Notes
Screening objectives are used to reduce a larger set of candidate factors to those warranting further study based on estimated effects, uncertainty, and scientific or practical relevance. Screening results commonly inform a subsequent characterization or optimization study and do not by themselves establish causality or criticality.
Examples
- Identifying which buffer components significantly affect product purity in an affinity chromatography step.
Adapted From
- https://wolfson.huji.ac.il/purification/PDF/Others/GE_DOE_in_Protein_Production_and_Purification_Handbook.pdf
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
There are insufficient constructs to determine a set of necessary and sufficient conditions
Formal Axioms
First-Order Logic Axioms
StudyDesignScreeningObjective(x) → StudyDesignObjective(x)
Semi-Formal Natural Language Axioms
if x is a ‘study design screening objective’ then x is a ‘study design objective’