deamidated residue
IRI: https://spec.industrialontologies.org/ontology/construct/DeamidatedResidue
Defined In: https://spec.industrialontologies.org/ontology/biopharma/MolecularEntity/
SubClass Of: modified amino acid residue
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:independent continuant › bfo:material entity › chemical moiety › amino acid residue › modified amino acid residue › deamidated residue
Definition
modified amino acid residue in which a carboxamide group has been converted to a carboxyl group, involving a net gain of oxygen and loss of nitrogen and hydrogen
Explanatory Notes
This modification corresponds to deamidation of an amino acid residue such as asparagine or glutamine. The reaction converts the side-chain amide to a carboxyl group, typically yielding aspartate or glutamate within the peptide.
Examples
- Deamidated asparagine residue in a monoclonal antibody; Deamidated glutamine residue in a recombinant protein; Aspartate-like residue formed by deamidation of an asparagine residue within a peptide; Glutamate-like residue formed by deamidation of a glutamine residue within a protein.
Adapted From
- http://purl.obolibrary.org/obo/MOD_00400
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
This term is expected to remain primitive as the detailed treatment of chemical bonds, structure and formation is outside of the current scope of IOF. Other biological and chemical ontologies should be used for these purposes
Formal Axioms
First-Order Logic Axioms
DeamidatedResidue(x) → ModifiedAminoAcidResidue(x)
Semi-Formal Natural Language Axioms
if x is a ‘deamidated residue’ then x is a ‘modified amino acid residue’