relative abundance
IRI: https://spec.industrialontologies.org/ontology/construct/RelativeAbundance
Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaMaterial/
SubClass Of: ratio
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:specifically dependent continuant › bfo:quality › bfo:relational quality › ratio › relative abundance
Direct subclasses:
Definition
ratio that is determined by the magnitude of a specified member or subset of a defined group of material entities relative to the total magnitude of that group
Explanatory Notes
1) Relative abundance is defined only after choosing a defined group of material entities as the comparison basis. The group may be small, such as the set of glycoform entities considered for one protein in one material, or very large, such as all atoms of an element in the universe. 2) The numerator may correspond to one member of the group or the combined contribution of a subset of members. The denominator is the total contribution across the entire defined group of material entities. 3) In many analytical settings, the magnitudes used in the ratio are estimated from instrument responses according to a stated method and reporting convention. 4) The defined group used for the numerator and denominator provides the comparison basis for the ratio. The quality may inhere in a broader material entity that contains the members of that group, such as a culture, mixture, intermediate pool, or product lot, with the group specifying what the relative abundance is computed over
Examples
- % of high-mannose species at the end of a fed-batch step; relative abundance of a sequence variant in a drug substance lot
Adapted From
- https://goldbook.iupac.org/terms/view/14415 and https://www.wisdomlib.org/concept/relative-abundance
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
There are insufficient constructs to create a set of necessary and sufficient conditions
Formal Axioms
First-Order Logic Axioms
RelativeAbundance(x) → Ratio(x)
Semi-Formal Natural Language Axioms
if x is a ‘relative abundance’ then x is a ‘ratio’
Description Logic
SubClassOf: constr:Ratio