solution saturation state
IRI: https://spec.industrialontologies.org/ontology/construct/SolutionSaturationState
Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaMaterial/
SubClass Of: material state
Class Hierarchy
owl:Thing › bfo:entity › bfo:occurrent › bfo:process › material state › solution saturation state
Direct subclasses:
Definition
material state of a solution in which the dissolved solute concentration stays below, at, or above the solute’s equilibrium saturation concentration in that solution under prevailing conditions
Explanatory Notes
Prevailing conditions in this context are the environmental and compositional variables that determine the solute’s equilibrium solubility for that solution at that time, typically including temperature and pH, and, where relevant, solvent composition (e.g., cosolvents), ionic strength, and the presence of other solutes/excipients that measurably shift solubility.
Examples
- a poorly soluble drug substance remaining dissolved above its equilibrium saturation concentration after solvent shift into an aqueous formulation vehicle; a formulation component remaining dissolved temporarily after cooling from room temperature to refrigerated storage; a sodium chloride buffer in which additional sodium chloride can still dissolve at 20 °C; a cell culture medium in which calcium and phosphate remain below the precipitation limit at pH 7.0 and 37 °C; a cell culture medium at the calcium phosphate solubility limit under pH 7.0 and 37 °C conditions; a bicarbonate-buffered medium with dissolved carbon dioxide at equilibrium under 5% CO₂;
Adapted From
- https://goldbook.iupac.org/terms/view/12730
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
There are insufficient constructs for creating a set of necessary and sufficient conditions
Formal Axioms
First-Order Logic Axioms
SolutionSaturationState(x) → MaterialState(x) ∧ ∃s (Solution(s) ∧ isMaterialStateOf(x, s))
Semi-Formal Natural Language Axioms
if x is a ‘solution saturation state’ then x is a ‘material state’ that ‘is material state of’ some ‘solution’