edge point
IRI: https://spec.industrialontologies.org/ontology/construct/EdgePoint
Defined In: https://spec.industrialontologies.org/ontology/biopharma/DesignOfExperiments/
SubClass Of: design point
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:generically dependent continuant › information content entity › design point › edge point
Definition
design point where one factor is set at its middle level and all other factors are set at high or low levels
Explanatory Notes
At an edge point, one factor is set at its middle level and the remaining factors are set at high or low levels. In a three-factor Box–Behnken design, the non-center design points are edge points. Edge points can support estimation of interaction and quadratic effects without including the corner points of the studied region.
Examples
- In a three-factor formulation study with excipient concentration levels of 2 %, 4 %, and 6 %, temperature levels of 20 °C, 25 °C, and 30 °C, and relative-humidity levels of 40 %, 55 %, and 70 %, the design point specifying 4 % excipient concentration, 20 °C, and 70 % relative humidity is an edge point.
Adapted From
- https://wolfson.huji.ac.il/purification/PDF/Others/GE_DOE_in_Protein_Production_and_Purification_Handbook.pdf
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
There are insufficient constructs to define a set of necessary and sufficient conditions.
Formal Axioms
First-Order Logic Axioms
EdgePoint(x) → DesignPoint(x)
Semi-Formal Natural Language Axioms
if x is an ‘edge point’ then x is a ‘design point’
Description Logic
SubClassOf: constr:DesignPoint