molecular toxin role
IRI: https://spec.industrialontologies.org/ontology/construct/MolecularToxinRole
Defined In: https://spec.industrialontologies.org/ontology/biopharma/MolecularEntity/
SubClass Of: molecular entity role
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:specifically dependent continuant › bfo:realizable entity › bfo:role › molecular entity role › molecular toxin role
Direct subclasses:
Definition
molecular entity role held by a molecular entity in a biological exposure setting in which its chemical or biochemical activity is treated as capable of causing damage or dysfunction to a cell or organism
Explanatory Notes
1) A molecular entity bearing a toxin role is distinguished by its capacity to cause damage or dysfunction when introduced or absorbed in sufficient quantity. This may include: (i) malfunction of cells; (ii) damage to the extracellular matrix; or (iii) cell damage to a degree that can lead to cell loss or cell death. 2) An entity bearing a molecular toxin role has a corresponding toxic disposition. This disposition is not modeled in the current version of the ontology and will be reconsidered in the future.
Examples
- Lipopolysaccharide molecule bearing a toxin role when present as a process-related impurity that can trigger harmful biological responses; Lipid A moiety bearing a toxin role in a context where it induces inflammatory activity; A mycotoxin molecule bearing a toxin role when contaminating a raw material;
Adapted From
- http://purl.obolibrary.org/obo/CHEBI_27026 and http://purl.obolibrary.org/obo/IDO_0000426
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
This term is expected to remain primitive as the detailed treatment of toxicity is outside of the current scope of IOF. Other biological and chemical ontologies should be used for these purposes
Formal Axioms
First-Order Logic Axioms
MolecularToxinRole(x) → MolecularEntityRole(x)
Semi-Formal Natural Language Axioms
if x is a ‘molecular toxin role’ then x is a ‘molecular entity role’