homodimeric antibody
IRI: https://spec.industrialontologies.org/ontology/construct/HomodimericAntibody
Defined In: https://spec.industrialontologies.org/ontology/biopharma/MolecularEntity/
SubClass Of: antibody
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:independent continuant › bfo:material entity › molecular entity › organic molecular entity › protein › antibody › homodimeric antibody
Definition
antibody consisting of two heavy chains and two light chains in which the two heavy chains have the same amino acid sequence and the two light chains have the same amino acid sequence
Examples
- Conventional monoclonal IgG antibody with two identical heavy chains and two identical light chains; IgG1 monoclonal antibody produced from a single antibody clone; Homodimeric Fc-containing antibody with matched heavy-chain pairing; Standard monospecific therapeutic antibody with two equivalent antigen-binding arms.
Adapted From
- https://www.cytivalifesciences.com/en/us/insights/capture-of-bispecific-antibodies-and-removal-of-product-related-impurities
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
There are insufficient constructs to define a set of necessary and sufficient conditions.
Formal Axioms
First-Order Logic Axioms
HomodimericAntibody(x) → Antibody(x)
Semi-Formal Natural Language Axioms
if x is a ‘homodimeric antibody’ then x is an ‘antibody’
Description Logic
SubClassOf: constr:Antibody