dead cell density

IRI: https://spec.industrialontologies.org/ontology/construct/DeadCellDensity

Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaMaterial/

SubClass Of: cell density

Class Hierarchy

owl:Thing › bfo:entity › bfo:continuant › bfo:specifically dependent continuant › bfo:quality › bfo:relational quality › density › number density › cell density › dead cell density

Definition

cell density that is the number of dead cells per unit size

Examples

• the dead cell density of a stressed CHO cell culture sample after viability analysis; the dead cell density of a bioreactor culture sample reported by an automated cell counter; the dead cell density of a thawed cell suspension after trypan blue staining; the dead cell density of a production culture sample during late-stage decline; the dead cell density of a cell suspension after exposure to cytotoxic conditions

Adapted From

• http://purl.allotrope.org/ontologies/quality#AFQ_0000361

Primitive Class

This class is declared primitive and it does not have necessary and sufficient condiftions defined.

Primitive Rationale

There are insufficient constructs for creating a set of necessary and sufficient conditions.

Formal Axioms

First-Order Logic Axioms

DeadCellDensity(x) → CellDensity(x) ∧ ∀p(hasMagnitudeBasisInBearerPart(x,p) → (Cell(p) ∧ ∃d(Dead(d) ∧ hasQuality(p,d))))

Semi-Formal Natural Language Axioms

if x is a ‘dead cell density’ then x is a ‘cell density’, and if x ‘has magnitude basis in bearer part’ some p, then p is a ‘cell’ that ‘has quality’ some ‘dead’

Description Logic

constr:DeadCellDensity ⊑ constr:CellDensity

constr:DeadCellDensity ⊑ ∀ constr:hasMagnitudeBasisInBearerPart .(constr:Cell ⊓ ∃ constr:hasQuality .constr:Dead)

SubClassOf: constr:CellDensity

SubClassOf: constr:hasMagnitudeBasisInBearerPart only (constr:Cell and constr:hasQuality some constr:Dead)