protein tertiary structure

IRI: https://spec.industrialontologies.org/ontology/construct/ProteinTertiaryStructure

Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaParameter/

SubClass Of: physical structure

Class Hierarchy

owl:Thing › bfo:entity › bfo:continuant › bfo:specifically dependent continuant › bfo:quality › morphological quality › physical structure › protein tertiary structure

Definition

physical structure of a protein that is the overall three-dimensional arrangement arising from the conformation of its polypeptide chain, including the spatial organization of its secondary structure elements relative to one another

Examples

• the folded three-dimensional structure of a single-domain antibody molecule; the folded structure of an antibody-derived single-chain variable fragment; the folded structure of a recombinant human growth hormone molecule; the folded three-dimensional structure of an erythropoietin molecule stabilized by disulfide bonds and glycosylation; the compact globular structure of a myoglobin molecule; the beta-barrel structure of a green fluorescent protein molecule

Adapted From

• https://www.fda.gov/media/182387/download

Primitive Class

This class is declared primitive and it does not have necessary and sufficient condiftions defined.

Primitive Rationale

There are insufficient constructs for creating a set of necessary and sufficient conditions

Formal Axioms

First-Order Logic Axioms

ProteinTertiaryStructure(x) → PhysicalStructure(x) ∧ ∃p (Protein(p) ∧ qualityOf(x, p))

Semi-Formal Natural Language Axioms

if x is a ‘protein tertiary structure’ then x is a ‘physical structure’ that is the ‘quality of’ some ‘protein’

Description Logic

constr:ProteinTertiaryStructure ⊑ constr:PhysicalStructure

constr:ProteinTertiaryStructure ⊑ ∃ constr:qualityOf .constr:Protein

SubClassOf: constr:PhysicalStructure

SubClassOf: constr:qualityOf some constr:Protein