protein main charge variant classifier
IRI: https://spec.industrialontologies.org/ontology/construct/ProteinMainChargeVariantClassifier
Defined In: https://spec.industrialontologies.org/ontology/biopharma/MolecularEntity/
SubClass Of: protein charge variant classifier
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:generically dependent continuant › information content entity › denoter › classifier › charge variant classifier › protein charge variant classifier › protein main charge variant classifier
Definition
protein charge variant classifier that classifies a molecular entity population composed of proteins or protein fragments as having charge-related analytical behavior comparable to the reference protein form under the relevant analytical conditions
Explanatory Notes
A main charge variant classifier classifies the protein or protein-fragment population whose charge-related analytical behavior is comparable to the reference protein form specified by the relevant product or design specification. In many charge-variant methods, this population corresponds to the main analytical peak, band, or region. The term main does not imply that the classified population is chemically homogeneous, nor does it imply that all non-main charge variants are impurities.
Examples
- a classifier that classifies the main monoclonal antibody peak population in cation-exchange chromatography; a classifier that classifies the protein population with pI comparable to the reference protein form in capillary isoelectric focusing; a classifier that classifies the main electrophoretic band population under a product-specific charge variant method;
Adapted From
- https://pmc.ncbi.nlm.nih.gov/articles/PMC5392216/ and https://www.chromatographyonline.com/view/charge-variant-profiling-biopharmaceuticals and https://www.agilent.com/cs/library/applications/compendium-chargevariant-advancebio-5994-0034EN-us-agilent.pdf?srsltid=AfmBOorRMu0dQH4wotghCeKwXSMCdNuuNsAEkA06EkLXupvMO6SBKJaN
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
There are insufficient constructs to create a set of necessary and sufficient conditions.
Formal Axioms
First-Order Logic Axioms
ProteinMainChargeVariantClassifier(x) → ProteinChargeVariantClassifier(x)
Semi-Formal Natural Language Axioms
if x is a ‘protein main charge variant classifier’ then x is a ‘protein charge variant classifier’